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The cells in the testicles that turn into sperm, or germ cells, are where the majority of testicular malignancies start. About 90% of cases of testicular cancer are caused by these cancers, also referred to as testicular germ cell cancer. Seminoma and nonseminoma are the two main kinds of testicular germ cell cancer that can develop. Nonseminomas, in contrast to seminomas, grow and spread more quickly, necessitating more prompt and intensive therapy to ensure a successful outcome. Only about 2% of male cancer cases are testicular cancer, so it is still a rare disease. In the United States in 2023, experts project fewer than 10,000 new diagnoses of testicular cancer and fewer than 500 deaths due to the disease. Testicular cancer has a low incidence, although it mainly strikes young men between the ages of 15 and 35.

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